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CBD OIL 500MG

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Cannabidiol (CBD) Oil is one of 123 phytocannabinoid compounds in the hemp cannabis plant. The THC Content is less than 0.3%. This CBD Oil is made by “COLORADO CBD”. The FDA considers hemp oil (and it’s derivative CBD) to be a dietary supplement (not a medication), since it is made from industrial hemp plants. If you live in the US, this means you don’t need a prescription and can legally purchase and consume hemp-based cannabidiol in any state.

According to a 2013 review published in the British Journal of Clinical Pharmacology, CBD OIL may treat the following conditions:

√ Reduce Nausea and Vomiting

√ Combats Inflammatory and Pain Disorders

√ Combats Anxiety and Depression Disorders

COLORADO CBD is tested by independent laboratories to assure a consistent, dependable level of potency and quality and is 100% USA grown and extracted. It is produced without organic solvents and NO pesticides or sprays are used on the hemp plants.

This Product Can Be Shipped Only to USA

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Description


Colorado CBD OIL

CBD OIL – Cannabidiol from hemp. CBD offers the benefits of medical marijuana but it is 100% legal. Through the use of selective breeding techniques, this CBD Oil has been created from cannabis varieties with high levels of CBD and negligible levels of THC.

Used Medically For Centuries

The use of any part of the marijuana plant medicinally continues to be a controversy. Regardless of the fact that marijuana and cannabis oil preparations have been used in medicine for hundreds of years, the fact that marijuana was banned in the 1930’s has made it off-limits. The controversy lies in the case that other harmful substances such as tobacco and alcohol are legal in Western society.

Science has been delving into the mysteries of marijuana only to uncover the truth. Marijuana is non-addictive, non-carcinogenic and fairly harmless. Nobody has ever died of an overdose. And, adult use may even be beneficial to the health. (There is insufficient evidence to indicate whether or not the growing brain of an adolescent or child could be negatively affected by imbibing marijuana.)

In recent years, marijuana has been embraced by many both recreationally and therapeutically. When the numerous benefits of CBD or Cannabidiol are taken into consideration, to deny the clinical potential of CBD is just not right.

Cannabis Plant

Cannabis is the species name for the entire plant. There are several varieties of cannabis. Other well-known names for Cannabis are weed and marijuana. Cannabis has long been used for hemp fiber, for hemp oils, for medicinal purposes, and as a recreational drug. The Cannabis plant contains dozens of cannabinoids, or active ingredients. The FDA considers hemp oil (and it’s derivative CBD) to be a dietary supplement (not a medication), since it is made from industrial hemp plants. If you live in the US, this means you don’t need a prescription and can legally purchase and consume hemp-based cannabidiol in any state.

Free and fast trackable shipping as standard on all orders over $99. USA Only.

CBD vs THC

Out of all the cannabinoids, two stand out: tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabis is all about these two main Cannabinoids, THC and CBD. The main difference between THC and CBD is that THC is known for its psychoactive properties, and is the reason people feel buzzed after ingesting marijuana. On the other hand, CBD is a non-psychoactive cannabinoid and actually works to calm your high. It is also believed that CBD has numerous medicinal benefits, such as anti-inflammatory properties and the ability to protect your neurons from injury or degeneration.

THC

Tetrahydrocannabinol (THC) is the most common psychoactive cannabinoid. It is best known for causing the high you get from smoking marijuana. However, it also seems to have a number of medical applications, such as, pain relief, nausea, depression and the ability to improve appetite, among many other things. Even after years of research, its status as an illegal drug has made information about this cannabinoid very difficult to come by.

Furthermore, these are little known facts about THC, as follows: 1. THC is used in FDA-approved pharmaceuticals 2. THC can protect brain cells and stimulate their growth 3. Chemicals like THC are produced naturally in the body.

CBD

Cannabidiol (CBD) is the second most common cannabinoid. Although it has no psychoactive effect, it appears to improve mood and alleviate pain. Interestingly, CBD has received a lot of attention lately because of its antipsychotic effect that calms the nervous system. Studies suggest that it may help with epilepsy, schizophrenia and a number of other ailments. In the latest study, published in the journal “Neuropsychopharmacology”, both Dutch and British researchers reviewed more than 66 past studies on CBD and psychosis, and concluded that the compound offers a number of advantages over current drugs. The authors point out that CBD, unlike a vast majority of medicines, appears to have no noticeable side effects and no lethal dose. Several lines of evidence, including animal and human studies, also support its effectiveness as an antipsychotic medicine.

Characteristics Of Colorado CBD Oil

Scientific research now shows the many benefits of CBD Cannabidiol. The Colorado CBD Oil benefits are real because CBD does produce strong medicinal and therapeutic effects for even the most common conditions. Colorado CBD Oil has also been shown to relieve pain and has an anti-inflammatory effect that reduces swelling. CBD Oil may alleviate severe social anxiety and offer many other benefits. An increasing number of physicians, scientists and consumers are learning about these health benefits and incorporating CBD into a healthy lifestyle plan.

While THC has the propensity to cause anxiety and paranoia in some people, CBD effectively counteracts those side effects. CBD is like the opposite book-end or balance to THC. This is why, in part, that CBD Oil’s benefits extend so far as to be used in clinical trials on young children with epilepsy.

Another major difference between THC and CBD is that CBD promotes wakefulness while cannabis containing high levels of THC is commonly used for its sleep-inducing effects.

What Is CBD?

There are more than 60 different cannabinoids found in marijuana. CBD (Cannabidiol) is just one of them. In most weed, CBD levels are lower than THC (Tetrahydrocannabinol) because most weed is grown (and bred) for the purpose of getting stoned. It’s the CBD that balances out the high, while THC is responsible for the psychoactive aspect. Cannabidiol is the non-psychoactive element of the Cannabis plant. We’re just beginning to discover the benefits that this component of the plant has to offer.

Until now, most strains of marijuana have been developed for their abundant levels of THC so that high-CBD strains have been less common. With the medical community focusing on the therapeutic effects of CBD, that is starting to change. In fact, CBD reduces the intoxicating effects of THC, as well as unpleasant effects like paranoia and memory impairment.

How CBD Differs From Other Cannabinoids

Studies on the other cannabinoids of marijuana have shown that they act as ligands. That means they dock onto the binding site of a protein and modulate the behavior of the receptor. While CB1 receptors are widely distributed, they are more abundant within areas of the brain. These areas include those related to movement, coordination, pain, sensory perception, cognition, emotion, autonomic and endocrine functions. CB2 receptors, on the other hand, reside mostly in the immune system and reduce inflammation and certain kinds of pain. Cannabinoids have similarities but will act uniquely at every various receptor.

CBD is different in that it has very little effect on CB1 and CB2 receptors. This explains why it does not have mind-altering effects.

Benefits Of Colorado CBD Oil

Pain Relief – Colorado CBD Oil reduces pain-causing inflammation and inhibits neuronal transmission in pain pathways. A study published in the Journal of Experimental Medicine in 2012 cited that CBD significantly suppressed chronic inflammatory and neuropathic pain in rodents without causing analgesic tolerance.

Antipsychotic Effects – Research has shown that CBD produce antipsychotic effects and seems to have a pharmacological profile like atypical antipsychotic drugs as seen using behavioral and neurochemical techniques in animal studies. Research also shows that CBD oil prevents human experimental psychosis and is safe and effective in clinical trials with patients of schizophrenia.

Calms Anxiety – CBD has an anxiolytic-like effect, shown to reduce anxiety in patients with social anxiety disorder. It has been suggested by researchers that it may be effective in panic disorder, obsessive compulsive disorder and post-traumatic stress syndrome.

Fights Cancer! – CBD possesses antiproliferative, proapoptotic effects that inhibit cancer cell migration, adhesion and invasion. In a 2006 study that was published in the Journal of Pharmacology and Experimental Therapeutics, CBD potently and selectively inhibited the growth of breast tumor cell lines and exhibited significantly less potency in non-cancer cells. In 2011, researchers showed that CBD induced a concentration-dependent cell death of both oestrogen receptor-positive and oestrogen receptor-negative breast cancer cells. It was also discovered that the effective concentration of CBD in tumor cells had little ill-effect on non-tumorigenic mammary cells. CBD Oil was also found effective in inhibiting the invasion of lung and colon cancer and has been used to treat leukemia.

Nausea Relief – For centuries, marijuana has been used to treat nausea and vomiting. CBD helped to get rid of nausea and vomiting in animal studies. In a 2012 study published in the British Journal of Pharmacology, CBD demonstrated anti-nausea and antiemetic effects when administered to rats.

Stops Seizures – Sixteen of 19 parents reported a reduction in their child’s seizure frequency while taking CBD oil. Other effects included increased alertness, improved sleep and better mood. In preliminary results of a study in 2014 that included children with treatment-resistant epilepsies in an expanded access “Compassionate Use Program”, patients were given a purified 98% oil-based CBD extract. After three months, 39% of the 23 patients had more than a 50% reduction in seizures with a 32% median reduction. CBD is generally well-tolerated in doses of up to 25 mg per kilogram of body weight.

Treats Diabetes – CBD Oil significantly reduced the incidence of diabetes in non-obese diabetic mice from an incidence of 86% in non-treated mice to an incidence of 30% in CBD-treated mice in a study done in 2006. The American Journal of Medicine published a study in 2013 that showed the effect of marijuana on glucose, insulin and insulin resistance among American adults. Of the subjects participating in the study, 579 were currently using marijuana and 1,975 had been users of marijuana in the past. Researchers discovered that current marijuana use was associated with 16% lower fasting insulin levels. It was also found that current marijuana use was associated with smaller waist circumferences – a factor that is a precursor to diabetes symptoms.

Supports Cardiovascular Health – The British Journal of Clinical Pharmacology published a study in 2013 that reported CBD Oil protects against the vascular damage brought on by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models. CBD Oil also reduced the vascular hyperpermeability (the cause of leaky gut) that is associated with this environment.

Treats Withdrawal Symptoms – Researchers say that it is possible to use cannabis to quit crack. A study at St. Paul Hospital in Vancouver involving 122 participants looked at the intentional use of cannabis to reduce crack cocaine use. The findings were reported in CS Globe. It said that 620 instances of people who chose to use cannabis to quit crack over a period of time had decreased their use of crack. These results mirror research done in Brazil where the use of cannabis therapeutically reduced the cravings for crack cocaine. 68% of the participants stopped using crack and reported reduced cravings, which helped them to overcome their addiction.

How Does CBD Reduce Cravings?

There is a scientific basis for the idea that CBD Oil can help to lessen and illuminate cravings. First we should try to understand what exactly causes cravings. According to the scientists, an increase in the transmission of glutamate is the root of the problem. Glutamate is a neurotransmitter located in the brain’s hippocampus. We experience these cravings as irritability, anxiety, palpitations or sweating. It’s these strong cravings that cause people to relapse even years after conquering their addiction.

It has been proven that CBD can reduce ‘cue-induced cravings’ which are cravings brought on by a “trigger”. (For example: When a smoker has a cup of coffee, he may start to crave a cigarette because it’s associated with drinking the coffee.) CBD’s non-psychoactive compound combats these triggered cravings. It also reduces the anxiety levels of heroin and opioid dependent people while they’re trying to quit their dependency.

CBD Can Reverse Brain Changes

Studies showed that rats who had become addicted showed brain changes due to their addiction. After only 7 days of CBD treatments, their brains changed back. Addiction changes the way the brain functions but CBD may be able to reverse those changes. This is great news for anyone trying to kick an addiction.

How Do I Use Colorado CBD Oil?

Colorado CBD Oil can be taken by placing a few drops under the tongue.

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References

1. Effects of Cannabidiol (CBD) on Regional Cerebral Blood Flow. – Read Full Article

2. Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients. – Read Full Article

3. The Medicinal Uses of Cannabis and Cannabinoids. – Read Full Article

4. Cannabinoids in the management of difficult to treat pain. – Read Full Article

5. Cannabinoids as novel anti-inflammatory drugs. – Read Full Article

6. Cannabinoids as therapeutic agents in cancer: current status and future implications. – Read Full Article

7. Important new clinical applications for this phytocannabinoid? – Read Full Article

8. ​Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells – Read Full Article

​9. Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome. – Read Full Article

10. Antibacterial cannabinoids from Cannabis sativa: a structure‐activity study. – Read Full Article

11. CBD compound in cannabis could treat diabetes, researchers suggest. – Read Full Article

12. Regulation of nausea and vomiting by cannabinoids. – Read Full Article

13. Interaction between non‐psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti‐ nausea or anti‐emetic effects of cannabidiol (CBD) in rats and shrews. – Read Full Article

14. Cannabidiol, a non‐psychotropic component of cannabis, attenuates vomiting and nausea‐like behaviour via indirect agonism of 5‐HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. – Read Full Article

15. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. – Read Full Article

16. Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report. – Read Full Article

17. Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. – Read Full Article

18. Anti‐inflammatory effects of the cannabidiol derivative dimethylheptyl‐cannabidiol ‐ studies in BV‐2 microglia and encephalitogenic T cells. – Read Full Article

19. Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. – Read Full Article

20. Anti‐inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS‐stimulated macrophages. – Read Full Article

21. The nonpsychoactive Cannabis constituent cannabidiol is a wake‐inducing agent. – Read Full Article

22. Potential Effects of Cannabidiol as a Wake‐Promoting Agent. – Read Full Article

23. Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury. – Read Full Article

24. Cannabidiol as potential anticancer drug. – Read Full Article

25. The Antitumor Activity of Plant‐Derived Non‐ Psychoactive Cannabinoids.- Read Full Article

26. Cannabis and Cannabinoids. – Read Full Article

27. Cannabinoids inhibit human keratinocyte proliferation through a non‐CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. – Read Full Article

28. The relationship between cannabidiol and psychosis: A review. – Read Full Article

29. A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation. – Read Full Article

30. Could cannabidiol be used as an alternative to antipsychotics? – Read Full Article

31. Cannabidiol attenuates haloperidol‐induced catalepsy and c‐Fos protein expression in the dorsolateral striatum via 5‐HT1A receptors in mice. – Read Full Article

32. Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects. – Read Full Article

33. A systematic review of the antipsychotic properties of cannabidiol in humans. – Read Full Article

34. Multiple mechanisms involved in the large‐spectrum therapeutic potential of cannabidiol in psychiatric disorders. – Read Full Article

35. Cannabidiol Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System. – Read Full Article

36. Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug. – Read Full Article

37. Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects. – Read Full Article

38. Endocannabinoid system: Role in depression, reward and pain control (Review). – Read Full Article

39. Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation? – Read Full Article

40. Does cannabidiol have a role in the treatment of schizophrenia? Cannabinoids and schizophrenia: therapeutic prospects. – Read Full Article

41. The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer’s disease. – Read Full Article

42. Long‐term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer’s disease transgenic mice. Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects. – Read Full Article

43. Evidences for the anti‐panic actions of Cannabidiol. Read Full Article

44. Purified Cannabidiol, the main non‐psychotropic component of Cannabis sativa, alone, counteracts neuronal apoptosis in experimental multiple sclerosis. Read Full Article

45. The Profile of Immune Modulation by Cannabidiol (CBD) Involves Deregulation of Nuclear Factor of Activated T Cells (NFAT). – Read Full Article

46. Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells. – Read Full Article

47. CBD & Inflammatory Bowel Disease. – Read Full Article

48. Cannabidiol, a Major Non‐Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts. – Read Full Article

49. CBD‐enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. Read Full Article

50. Perceived efficacy of cannabidiol‐enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox‐Gastaut syndrome. Read Full Article

51. Cannabidiol: Promise and Pitfalls. – Read Full Article

52. HU‐446 and HU‐465, Derivatives of the Non‐psychoactive Cannabinoid Cannabidiol, Decrease the Activation of Encephalitogenic T Cells. – Read Full Article

53. A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis. – Read Full Article

54. Transdermal cannabidiol reduces inflammation and pain‐ related behaviours in a rat model of arthritis.- Read Full Article

55. Cannabidiol limits Tcell‐mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. – . Read Full Article

56. Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome. – Read Full Article

57. Differential effectiveness of selected non‐psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrheic skin and acne treatment. – Read Full Article

58. Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. – Read Full Article

59. Cannabidiol improves lung function and inflammation in mice submitted to LPS‐induced acute lung injury. – Read Full Article

60. Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double‐blind trial. – Read Full Article

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