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Centrophenoxine * Lucidril * – 250 mg, 60 Capsules


Centrophenoxine is a derivative of the well-researched brain-supplement DMAE, and it’s marketed under the trade name Lucidril. It is one of the oldest and most well-researched nootropic on the market today.  It’s used around the world for its ability to treat degenerative brain conditions, although it’s recently gained popularity for its ability to enhance cognition and improve overall brain health.

  • Superior Cholinergic Supplement
  • Boosts Brain Health & Fights Aging
  • Improves Memory, Learning & Alertness
  • Useful in Treatment of Dementia
  • Reduces Lipofuscin & Beta-amyloid Residue

Centrophenoxine has been marketed under the trade name “Lucidril”.  In medical science, Centrophenoxine has been shown to help with Alzheimer’s, Dementia and general cognition.

Suggested Use: As a dietary supplement take 1 or 2 capsules daily or as directed by your health care professional.



Centrophenoxine / Lucidril

What is Centrophenoxine?

Centrophenoxine is made of two biochemicals, parachlorophenoxyacetate (pCPA), which is a plant-hormone resembling compound called an auxin and dimethylaminoethanol (DMAE) a natural substance found in the brain. For over 40 years Centrophenoxine has been used and studied for the treatment of Alzheimer’s and Senile Dementia’s and is also one of the most popular brain-energizing, anti-aging products. Do not consider this product until you have consulted with a medical professional.

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Centrophenoxine: A Superior Cholinergic

Nootropic users know that choline is an absolute must when it comes to boosting brain power. Choline, a B vitamin-like substance which is both derived from food and made in the body, is essential for optimal brain function in several ways.

Centrophenoxine can serve to generate choline in the liver, and provide both DMAE and choline to the brain. Centrophenoxine increases the amount of choline available to your brain, and for that reason it stacks very well with some commonly used nootropics from the racetam family, like piracetam, aniracetam, oxiracetam and phenylpiracetam, which increase acetylcholine activity.

Centrophenoxine actually passes the blood-brain barrier and can increase the amount of acetylcholine manufactured in your brain. So while it’s not technically a choline source (as is sometimes claimed!), it functionally performs the same job as choline supplements.

Centrophenoxine History

Centrophenoxine, also known as Lucidril® and meclofenoxate, is one of the older nootropic drugs- it was developed in 1959 at the French National Scientific Research Center. It is one of the earliest nootropics, and has been vastly studied. The benefits are supported by over 50 years of research, making this supplement well-known and trusted.

Centrophenoxine is a compound of two other biochemicals- dimethyl-aminoethanol (DMAE) and parachlorphenoxyacetic acid (PCPA). DMAE is found naturally in some foods, especially fish, and is also, a natural metabolite of choline in the human body. The presence of high amounts of DMAE in fish may be the basis for the “folk wisdom” that “fish is brain food.” PCPA is a synthetic version of plant growth hormones called “auxins.”

“Pharmacokinetic studies of centrophenoxine revealed that … much higher levels of DMAE were found in the brain after centrophenoxine treatment, as compared to DMAE alone, since apparently the esterified form of DMAE with PCPA penetrates much easier the blood-brain barrier.”

How Does Centrophenoxine Work?

In the Central Nervous System, Centrophenoxine increases levels of the neurotransmitter acetylcholine and enhances neuronal glucose (the main fuel for the brain) and oxygen uptake which indicate increased brain energy production. Centrophenoxine also increases neuronal RNA (derived from DNA) which tell neurons to repair cell damage and create proteins to encode memory. Lipofuscin is accumulated during our lifetime due to poor cell health and is basically biochemical garbage. When large deposits form around cells, the function becomes impaired thus causing a drop of RNA and protein production as we age. Centrophenoxine is excellent at reducing and even removing lipofuscin. Low lipofuscin levels usually mean healthy cellular function and high levels poor.

Benefits of Centrophenoxine

Centrophenoxine offers a wide range of benefits for both brain and body:

Better Memory – Centrophenoxine is best known for its considerable abilities as a memory booster. Its primary action is providing additional choline and enabling the production of acetylcholine, the neurotransmitter that is most closely tied to cognitive function in general and memory in particular.

Enhanced Fluid Intelligence – Centrophenoxine can enhance fluid intelligence, or the ability to solve problems without relying on acquired knowledge.

Improved Overall Brain Function – Centrophenoxine is considered a neuro energizer because it stimulates glucose uptake, oxygen consumption, and carbon dioxide production. The additional oxygen and glucose add to its nootropic effects, making learning easier, thought clearer, and all of the brain’s functions more efficient.

Increased Energy – Many users find that centrophenoxine has a mild stimulant effect. While it energizes without creating the jittery feelings that amphetamines or other stimulants cause, its energy boost is enough to disrupt regular sleep patterns if taken late in the day.

Anti-aging – Research shows that centrophenoxine is an aggressive free radical scavenger and powerful antioxidant that protects the brain from age-related deterioration, flushes out toxins, and repairs damaged cells.

Helps Patients with Alzheimer’s and Dementia – When used for clinical application, Centrophenoxine has been used with other treatments to help patients with Alzheimer’s and dementia. Further research is being conducted in order to improve mood and potentially treat ADHD.

Centrophenoxine Dosage

A typical, effective recommended dosage is between 250 mg and 1000 mg a day. Start with 250 mg a day and increase it as desired, up to 1000 mg. Above that is not recommended.

Caution is necessary and Centrophenoxine is a powerful enhancer of brain and peripheral nervous system acetylcholine levels. Excessive levels of acetylcholine can cause problems such as headaches, neck, jaw and shoulder muscle tension, insomnia, irritability, agitation and restlessness.

If any of these occur, simply discontinue Centrophenoxine for a few days and then try a reduced dosage. Discuss with your medical practitioner. Also, those with major depression, mania, seizure disorders or Parkinson’s Disease should avoid Centrophenoxine, as too much acetylcholine may worsen these conditions. Pregnant women should avoid Centrophenoxine.

Elderly people with significant intellectual decline may chose 3 to 6 Centrophenoxine tablets (250mg) per day taken preferably with breakfast and lunch, in order to avoid insomnia. For the non-elderly wishing to utilize the brain boosting benefits of Centrophenoxine, perhaps only 1 or 2 Centrophenoxine tablets (250mg each) daily with breakfast or lunch. Excessive acetylcholine levels can accumulate virtually un-noticed so it is advisable to miss a couple of days each week. Check with your medical professional.

Centrophenoxine Side Effects

Centrophenoxine is safe and nontoxic at every level of dosage and is very well tolerated. However, some users have experienced mild and minor side effects, including headaches, fatigue, nervousness, nausea, diarrhea, and mild dizziness. At higher doses some jaw clenching may occur.

If any of these effects present themselves, the best course of action is to simply reduce the dose or discontinue use for a few days until everything is resolved. This supplement is not recommended for pregnant women, those with high blood pressure, and certain convulsive orders such as epilepsy.

Centrophenoxine Stacking Advice

Centrophenoxine increases the amount of choline available to your brain, and for that reason it stacks very well with some commonly used nootropics from the racetam family, like piracetam, aniracetam, oxiracetam and phenylpiracetam, which increase acetylcholine activity.

Piracetam and Centrophenoxine Stack

Piracetam and Centrophenoxine stack is highly complementary. In simple words, Piracetam tells your brain to release more acetylcholine and Centrophenoxine makes it possible for your brain to release more acetylcholine.

The racetams essentially increase the demand for choline in your body. In some cases, taking racetam can cause headaches if you do not have enough of choline stored in your body.

Choline is found in a lot of foods that we commonly eat, but its presence is often not high enough to meet daily requirements. In fact, population studies have determined that 9 in every 10 Americans is Choline Deficient. If your Choline levels are too low, Piracetam can cause your supply to become depleted which has been known to result in headaches.

That is why taking Piracetam and Choline together has become the norm.

Further Information on Centrophenoxine

During a study of elderly but healthy individuals, who were suffering with intellectual deterioration it was found that after only a few weeks taking Centrophenoxine they increased the storage of new information and their ability to access long term memories combined with increased vigilance and alertness.

Centrophenoxine also called Meclofenoxate but most commonly recognized under its brand name Lucidril, is one of the original anti-aging, neuro-energizing products having been used for over 40 years and studied for approximately 50. It is made from two biochemicals: DMAE and pCPA as mentioned above.

An early discovery found that Centrophenoxine effectively reduces lipofuscin levels. Lipofuscin is a fine granular yellow brown pigment, the remains or garbage accumulated over a lifetime. Considered one of the aging pigments, lipofuscin is found in most of our organs cells. The more lipofuscin in the cells, the less functional they become to a point where the cells may die. Animal and human studies have concluded that low lipofuscin levels correlates with healthy cellular function and high the opposite. Centrophenoxine has shown to be very efficient in removing this garbage.

In aged animals with high lipofuscin levels experiments showed that centrophenoxine considerable improved their memory and learning abilities.

DMAE is the major component in Centrophenoxine and DMAE, when added to the correct methyl group, creates choline which in turn helps to make valuable biochemicals like acetylcholine. When oxidized choline can make betaine which is important in ridding homocysteine – a toxic risk factor in heart disease. Choline levels are also considered to be a contributing factor in Alzheimer’s Disease. Choline is found naturally in certain foods such as liver, meat and eggs.

Those lacking in these natural sources of choline could chose a choline supplement but most of these are broken down by the gut. This is not the case with the DMAE in Centrophenoxine, leaving the liver to convert it to as much choline as needed. Also, DMAE prevents choline from being irreversibly oxidized to betaine and it passes through the blood brain barrier far more easily. With the help of an enzyme called “CAT”, choline is converted into acetylcholine a neurotransmitter with a responsibility for learning and memory. In Alzheimer’s Disease and aging itself, cholinergic neurons tend to under produce acetylcholine.

Not to be confused with Acetylcholine itself, the popular brain nutrient ALC or Acetyl-L-Carnitine increases CAT activity, thus increasing the production of acetylcholine. It has been found that for optimizing the effect on cognitive enhancement, learning and memory, some use a combination of ALC, Centrophenoxine and Piracetam.

In a study of healthy elderly individuals who were suffering from significant intellectual deterioration, after just a few weeks, Centrophenoxine increased storage of new information into long term memory and increased vigilance and alertness. Centrophenoxine increases brain energy (ATP) production by enhancing neuronal glucose and oxygen uptake. It also increases neuronal RNA and protein production which repair damaged cells and encode memory. This function decreases with age especially when the nucleus around the cells are covered with lipofuscin and as mentioned above, Centrophenoxine reduces the levels of lipofuscin. The other component in Centrophenoxine, pCPA, is similar to plant auxins (hormones) which increase the RNA and protein production in growing plants.

Aging synapses deteriorate in their function but Centrophenoxine has been shown to increase the repair of the synapses that connect nerve cells to each other. So to conclude, due to the combination of the plant hormone like compound pCPA along with DMAE, Centrophenoxine could be best described as “the ultimate DMAE”.

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  1. A simple and sensitive HPLC method for quantification of the metabolin of meclofenoxate in human plasma. – Read Full Article
  2. Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson’s disease. – Read Full Article
  3. Effects of centrophenoxine on cholinephosphotransferase activity in maternal and fetal guinea pig lung.- Read Full Article
  4. Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice. – Read Full Article
  5. Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain.- Read Full Article
  6. Participation of adrenergic mechanisms in brain acetylcholine release produced by centrophenoxine. – Read  Full Article
  7. Behavioral alterations in rotenone model of Parkinson’s disease: attenuation by co-treatment of centrophenoxine. – Read Full Article

Additional information

Weight 0.5 lbs


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