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Picamilon – (100 mg x 60 capsules)

$27.99$89.56

Picamilon (also known as N-nicotinoyl-GABA, Pycamilon and Pikamilon) is a nootropic created in 1969 used for cognitive support.

  • Anxiety & Stress Relief
  • Learning & Memory Enhancement
  • Improved Concentration, Alertness & Mental Stamina
  • Brain & Body Relaxation Without Sedation
  • Improves Sleep

It provides a tranquilized yet energized state of being.

Suggested Use: As a dietary supplement, take 1 or 2 capsules daily or as recommended by your health care professional.

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Description


What Is Picamilon?

Picamilon is a generally well-tolerated nootropic or Smart Drug used for stress relief and anti-aging effects. It is widely used in the Russian medical community for treating stroke victims, depression, Asthenia, migraines and certain types of glaucoma. However, most users are interested in Picamilon for its neurogenic properties to improve their cognitive energy and focus. It has been compared to Phenibut, another GABAergic nootropic with a slightly different effect. The biggest difference is Phenibut’s sedative effect which doesn’t occur with Picamilon.

Picamilon is also known as nicotinoyl-gamma-Aminobutyric acid, a combination of niacin and GABA (gamma-aminobutyric acid). The actual chemical structure is 4-(pyridine-3-carbonylamino) butanoic acid or nicotinoyl-y-aminobutyric acid.

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Who Created It?

The All-Union Vitamin Scientific Research Institute of Russia created Picamilon in 1969 as a viable therapy for several medical conditions. It remains available only through prescription in Russia, though Picamilon is available over the counter in the US. The drug rights are owned by a Russian pharmaceutical company in Moscow.

How Does Picamilon Work?

After Picamilon crosses over the blood brain barrier, it goes through a transition via a hydrolytic reaction (a chemical reaction in which water is added to a substance) and is metabolized into niacin (Vitamin B3) and GABA. GABA produces an anxiolytic response (calming influence) in the brain by interacting with the brain’s receptors. Primarily, its effect is to moderate excessive neuronal activity that causes stress, negativity or panic.

Meanwhile, niacin works as a vasodilator, increasing blood flow and oxygen to the brain. So, although Picamilon is a prodrug which is inactive of itself, the metabolization of GABA and Niacin in the brain produces a balanced state of mind.

We can think of Picamilon as a vehicle that enables GABA to pass over the blood brain barrier by binding it with Niacin. Without this binding together of the two supplements, it would be repelled by the body’s filtering system.

The Effects Of Picamilon

The first reaction most users report is a feeling of calm clarity and stimulation. Without sedation, the mind becomes stress-free and able to peacefully relax. At the same time, this supplement increases mental energy and levels of awareness. That’s the effect of Niacin balancing some of the inhibitory influence of GABA by introducing an increase of oxygen and blood flow to the brain. There’s a dual action taking place with more energy being metabolized in the cells while, simultaneously, overactive neurons are being calmed down.

Performing cognitively, Picamilon enhances memory retention, recall, mental energy and focus. It also improves sleep patterns, calms stress and alleviates symptoms of depression.

It has been generally viewed as a safe nootropic in the Smart Drug community of users.

Picamilon Increases Alpha Brain Waves

A special Niacin Analog Pathway transports Picamilon across the blood-brain barrier where it helps to increase the production of Alpha brain waves.

(Alpha brain waves are the brain waves that occur while one is in deep relaxation, usually when the eyes are closed. Your brain produces these waves while you are slipping into a lovely daydream or during prayer or meditation. This is the optimal time to program the subconscious mind for success. Imagination, visualization, memory, learning and concentration are heightened during Alpha brain waves. It’s the gateway to your subconscious mind, lying at the base of your conscious awareness. Some say that the voice of Alpha is your sixth sense which grows in clarity the closer you get to it.)

Once Alpha brain waves are increased, the effects are anxiolytic which means you become free from stress and anxiety. You may forget what you had been worrying about it. It probably wasn’t all the important anyway. Your thoughts are peaceful. You are calm. –Yet, alert.

Picamilon reportedly switches off the incessant “mind chatter” or background noise in the brain that tends to disrupt thought patterns and prevent us from being able to focus properly.

Picamilon Relieves Social Anxiety

GABA is an inhibitory neurotransmitter. It is used by the brain to help us to relax and let go of the millions of concerns that come to us moment by moment. Anxiety is relieved. When taking such a GABAergic compound, most of us experience a tranquility and peace like never before. We may even feel less inhibited around others.

Lots of users have discovered that Picamilon helps them to overcome shyness in social settings so that they are more comfortable around other people and can speak more naturally. Some have reported that it helped them to stop dreading social interaction by lowering their inhibitions.

More Picamilon Uses

Interest in Picamilon may be attributed to the unique combination of its pharmacological properties. It possesses high cerebrovascular activity and nootropic effects but also a unique tranquilizing effect without myorelaxation effect. Picamilon has the ability to quickly restore mental and physical fitness for work, often lost through overstress. Studies have shown that Picamilon dramatically increases blood flow and circulation within the brain, and achieves results far superior to other nootropic agents. Picamilon’s tranquilizing action prevents the negative physiological effects of emotional stress, it helps moderate states of anxiety and depressed negative emotions but Picamilon doesn’t have any sedative qualities. Uniquely Picamilon provides a tranquilized yet energized state of being.

Picamilon is used in the capacity of a nootropic and vasoactive agent for mild to moderate ischemic disturbances of the cerebral blood circulation. It is also used for discirculatory encephalopathy, vegetative dystonia, craniocerebral traumas, neuroinfections and migraine. Picamilon has proven to be an effective medicinal treatment for patients with disorders of a neurotic level, with accompanying manifestations of anxiety, elevated irritability fear, emotional and vegetative instability. Additionally, in the elderly, Picamilon assists with senile psychosis and depressive disorders and it is used in the treatment of alcoholism and acute alcoholic intoxication.

More recently, Picamilon has been used in ophthalmological practice for diseases of the retina and the optic nerve and for primary open-angle glaucoma. It has also shown some value with urological disorders in children and adults in improving the function of the urinary bladder.

Picamilon Is A Cerebral Vasodilator

Because Picamilon is a Niacin precursor, it also contributes to the energy metabolism in the brain and supports neuron health. Part of the vitamin B complex, Niacin and has a number of functions both in the nervous system and in the gastro-intestinal tract.

Niacin is a cerebral vasodilator. This means it increases blood circulation to the brain. More blood means more oxygen. By delivering more oxygen and nutrition to the brain, Niacin delivers a greater capacity for mental stamina, resulting in higher levels of alertness and concentration.

This increase in blood flow leads to an overall improvement in brain health. Increased blood flow leads to better energy metabolism. Picamilon has a detoxifying effect on neurons because more of the toxins that build up in the cells are removed at a faster rate along with the improved blood flow.

Therefore, Picamilon helps those with anxiety, depression, sleep disorders and other mood disorders. It can be used by those who want an increase in focus and mental energy without higher levels of anxiety.

Natural Components

Picamilon is made up of two natural components, Niacin and GABA. These vitamins that occur naturally in the body are bound together in order to make them bioavailable. This combination restores GABA neurotransmitter levels in those who suffer from mood disorders. Cognitive abilities are also enhanced benefiting mental energy for better memory, focus and motivation.

Side Effects Of Picamilon

Although Picamilon is tolerated very well by the majority of users, in rare cases, it has been known to cause skin rashes and allergies. Other milder reported side effects are: lightheadedness, headache, low blood pressure, irritability, nausea and flushing of the skin.

No overdoses have been reported. However, it’s wise not to exceed the recommended dosage since this could worsen any potential risk of side effects.

Check with your doctor before using Picamilon, especially if you are taking any other medications or anti-anxiety supplement. It’s important to be particularly careful when using compounds that work on the GABA receptors. If you’re not certain whether your medications work on the GABA receptors, ask your doctor.

Cautions

Taken in appropriate dosages of less than 500 mg per day, Picamilon is safe and, when compared to other anxiolytics, less likely to present problems related to tolerance, withdrawal, addiction to abuse. Nevertheless, it should only be used under doctor supervision.

As a caution, it is noted that Picamilon is a weak Monoamine Oxidase Inhibitor (MAOI) which means it inhibits the activities of MAO —an enzyme that breaks down monoamines. (Dopamine and serotonin are monoamines which are broken down by MOA.) There are a number of anti-depressants that fall into the category of being MAOIs. Some herbal supplements like St. John’s Wort are also recognized as mild MAO inhibitors.

MAOIs can be dangerous when they interact with other drugs and even with certain foods. Although Picamilon is not believed to be in the same class as some of the more hazardous MAOI drugs, it’s important to be aware of the risks involved.

A potentially life-threatening condition called Serotonin Syndrome can result when foods containing tryptophan are consumed along with excessive doses of MAOI’s.

Additionally, Hypertensive Crisis, can occur if foods containing tyramine (a derivative of the amino acid tyrosine) are consumed along with MAOI’s. Hypertensive Crisis is a severe spike in blood pressure that can damage organs and requires immediate medical attention.

This is why MAOI’s are to be avoided as antidepressants unless absolutely necessary. Even though Picamilon is a mild MAOI, it’s wise not to combine it with other stronger drugs in this class due to potentiation of negative effects.

Other side effects can be caused by increased levels of Niacin in the brain. Depending on the dosage, Niacin can have side effects like skin flushes, eczema, and rashes.

At extremely high doses, Niacin can also cause hepatotoxicity. This can cause high blood sugar levels, which can be especially disconcerting for patients suffering from diabetes. At doses closer to 150 mg, these negative effects will not occur with Picamilon.

Recommended Dosage

Depending on your individual needs and the purposes for using it, the recommended dose for Picamilon varies greatly. Manufacturers generally suggest taking 50 – 100 mg per day for mood boosting and energy support. Larger doses are recommended for anxiety and stress relief, from 100 – 200 mg per day. It’s important to speak to your professional practitioner to tailor the dosage to your particular requirements.

Picamilon’s effects are usually felt within an hour and lasts between 4-6 hours. Picamilon provides a mild tranquilizing and mood stabilizing effect without sedation in small doses of 50mg three times per day. Higher doses of perhaps100mg three times per day will provide a stimulating influence increasing energy and endurance. Picamilon’s cognitive enhancing effects are cumulative and become more evident after several weeks of daily usage.

As noted by many clinicians and physicians the varied therapeutic actions of Picamilon opens up its wider possibilities as a medicinal and preventive product especially if you consider Picamilon’s low toxicity and lack of allergenic or carcinogenic properties and minimal side effects which include occasional headaches, dizziness and nausea.

Cycling The Dosage

Cycling the dosage of this nootropic will help your body not to develop a tolerance to the effects so that you can always experience the broadest benefits it has to offer. Picamilon is deemed safe for daily use but if you decide to use it only when needed, it will have a greater impact ongoing.

Stacking With Other Nootropics

Picamilon may be synergistic with other nootropics so reduce overall dosages. Acquire a medical professional’s advice should you be taking or plan to start taking Picamilon particularly if combining with potent vasodilators such as, ginkgo biloba, nicergoline, xanthinol nicotinate or vinpocetine. Avoid combining it with other MAO-A products like Deprenyl, GH3 or SSRI’s like Prozac unless under the recommendation of your physician. Anyone taking any other prescribed medication or pregnant / lactating women should consult a physician before using Picamilon. If using long-term, supervision and monitoring by a health care professional is recommended.

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References

  1. Gabaergic mechanism of cerebrovascular and neuroprotective effects of afobazole and picamilon. Read Full Article
  2. Preclinical prognosis of pyracetam and picamilon safety based on acute toxicity data. – Read Full Article
  3. Neurotrophic action of nicotinamide and nicotinoyl-GABA in rat brain in experimental Parkinsonism – Read Full Article
  4. Correction by nicotinamide and nicotinoyl-GABA of dopamine metabolism in rat brain in experimental Parkinson’s disease. – Read Full Article
  5. State of GABA-benzodiazepine receptor complex in diabetic neuropathy: effect of nicotinamide and nicotinoyl-GABA. – Read Full Article
  6. The effect of hypokinesia on depression and on the central GABA-A receptor complexes in the rat brain. – Read Full Article
  7. Evaluation of isonicotinoyl-gamma-aminobutyric acid (GABA) and nicotinoyl-GABA as pro-drugs of GABA. – Read Full Article
  8. Effect of nootropes on quantitative changes in the rat cerebral cortex GABA(A) receptor complexes under experimental hypokinesia conditions. – Read Full Article
  9. Oxidative stress correction by nicotinamide and nicotynol-GABA in diabetic neuropathy. – Read Full Article
  10. Pathogenetic treatment of central chorioretinal dystrophies with pikamilon. – Read Full Article
  11. Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome. – Read Full Article
  12. Effects of pikamilon on the brain water-electrolyte balance and in models of responses to the noise and vibration exposure, and their combination with motion sickness. – Read Full Article

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