Sulbutiamine (200 mg x 60 capsules)
$22.44 – $71.81
Sulbutiamine is an effective nootropic for boosting energy levels and increasing mental drive. Sulbutiamine, also known as “Arcalion”, is a water-soluble derivative of Vitamin B1 (Thiamine). Sulbutiamine is the drug recommended for asthenia, and psychic and somatic inhibition. Sulbutiamine administration results in nootropic benefits due to its effectiveness on the dopamine, glutamatergic, and cholinergic systems. When it is absorbed in the brain, sulbutiamine acts as a nootropic, improving energy production in the brain cells and enhancing cognitive ability.
√ A Brain Stimulant
√ Reduces Anxiety & Stress
√ Enhances Mood & Energy
Sulbutiamine is known to improve stamina and the ability to recover faster from illness and infection.
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Sulbutiamine – Source of Vitamin B1 or Thiamine
What is Sulbutiamine?
Sulbutiamine, also known as “Arcalion”, is a synthetic derivative of thiamine (vitamin B1), that offers a number of very real and impactful benefits for your cognitive function. It is a popular product that boosts mental and physical energy. It has positive effects for memory, depression, focus, fatigue and even erectile dysfunction. By increasing levels of Thiamine (vitamin B1) in the brain and body, it increases energy levels, improves cognitive ability and helps patients overcome chronic fatigue (asthenia). It also improves physical ability and stamina.
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Sulbutiamine is the drug recommended for asthenia, and psychic and somatic inhibition (Examine.com, 2015). Asthenia is defined by mental fatigue and there are several types: postpartum asthenia with symptomatic polymorphisms, viral and bacterial postinfection, emotional lability, intellectual asthenia, and psychological stress (Trialx.com, 2015). Sulbutiamine is obtained over the counter so exercise enthusiasts, and athletes use it to combat fatigue without a prescription (Medicalook.com, 2015). Some people experience a mild stimulatory effect without the common side effects of amphetamine. This is probably because it only affects dopamine and not other catecholamines. In addition, it has been reported to improve problems with memory. This is probably due to glutamate and acetylcholine activity. Some patients with Parkinson’s disease and schizophrenia that experience intellectual asthenia finds relief through use of Sulbutiamine. Cognitive effects have been demonstrated in several research projects, and some patients experience mood elevation for a short period of time.
During world war 1, Japanese sailors began to experience symptoms like loss of mental sharpness and fatigue. These turned out to be symptoms of a disease called Beriberi, caused by a deficiency of Vitamin B1 (Thiamine).
To combat these effects, the Japanese sought to develop a version of Vitamin B1 that lasted longer and reached the brain more easily. Because the blood-brain barrier – the thin safety membrane encasing your noggin – is highly polar, molecules that are non-polar can slip through quite easily. Decreasing the polarity of compounds to help them reach the brain has been a tactic known to scientists for a long time. The application of this tactic to Thiamine was to oxidize the substance without any other compounds present, creating a non-polar “dimer” of two bonded-together Thiamine molecules. In this form, the once-polar Thiamine skips much more easily into the brain.
Uses for Sulbutiamine
Sulbutiamine increases energy production in the brain cells to stimulate mental processes and address the root causes of chronic fatigue. It can also reduce the risk of degenerative cognitive diseases such as Alzheimer’s and provide effective relief for people who already have the illness.
As well as having nootropic properties, Sulbutiamine is a true age management product. It increases physical ability, stamina and longevity by boosting energy production throughout the body.
Because it helps the body convert food into energy more effectively, sulbutiamine caps are sometimes taken by people who train hard.
How Does Sulbutiamine Work?
Thiamin (vitamin B1) is essential for a healthy mind and body, fighting fatigue (asthenia), aiding concentration, and improving memory. However, Thiamin doesn’t easily cross the blood/brain barrier when taken as a supplement, which is where Sulbutiamine comes in.
Sulbutiamine is a form of Thiamine that crosses the blood/brain barrier quickly and easily.
Sulbutiamine is known to be cholinergic, glutamatergic and dopaminergic. The potentiation of glutamatergic activity in the Prefrontal Cortex is believed to be one of the Mechanisms of Action that grants Sulbutiamine the ability to increase memory functionality. Sulbutiamine is shown to cause an increase in cholinergic activities in the Hippocampus, this area of the brain plays a pivotal role in the consolidation of both short and long-term memory as well as spatial navigation and memory. Another plausible cause of Sulbutiamine improving cognition and memory is through the suppression and reduction of dopamine released in the Prefrontal Cortex. These various Mechanisms of Action make Sulbutiamine an understandable choice in improving cognitive and memory abilities.
To improve physical capabilities,Sulbutiamine helps the body convert food into energy more efficiently. It also improves the function of the central nervous system by increasing levels of key neurotransmitter acetylcholine and strengthens “myelin sheaths”, the protective coverings of our nerves.
Benefits of Sulbutiamine
By increasing energy in the brain and body and stimulating the central nervous system, Sulbutiamine may:
- Improve alertness, concentration and memory.
- Address the root causes of chronic fatigue and improve patients energy levels.
- Increase libido and improve erectile function in men.
- Protect nerves and their protective coverings.
- Alleviate the symptoms of degenerative cognitive disorders such as Alzheimer’s disease.
Development, trials and approvals
In clinical trials, Sulbutiamine has been shown to improve concentration and alertness, quicken reaction times, and significantly enhance memory, as well as lessening the symptoms of Alzheimer’s Disease. It has also been shown to improve physical ability and stamina and enhance libido and erectile function in men.
Sulbutiamine has been used to overcome anxiety disorders and may improve the brain’s resistance to stressful or difficult situations.
Sulbutiamine dosage is usually 600 mg per day, taken in three 200 mg doses, one in the morning and one in the afternoon and another in the evening. However, some manufacturers recommend different doses and you should always follow your medical professional’s advice.
Sulbutiamine Side Effects
Sulbutiamine has very few side effects. In a small percentage of cases, people have reported a mild skin allergy after taking Sulbutiamine caps, and this is slightly more frequent in elderly people.
When taken in very large quantities, sulbutiamine may interfere with treatment for bi-polar disorder.
Sulbutiamine Stacking Advice
Sulbutiamine + Aniracetam + Choline Stack
Sulbutiamine stacks well with the racetam class of nootropics. Among the racetams, stacking sulbutiamine with aniracetam is a common choice due to aniracetam’s similar effects on cognition and mood, really enhancing overall effects. Meanwhile, choline works in concert with Aniracetam and sulbutiamine to ensure maximum memory power and capacity for concentrated attention. When it comes to pure concentrated choline content, Alpha GPC has the edge, as it contains 40 percent by weight.
Further information on Sulbutiamine
Sulbutiamine is a highly efficient Vitamin B1 derivative used primarily to fight asthenia – lack of strength or energy. Sulbutiamine (more commonly known as Arcalion) is the only anti-asthenic compound known to cross the blood-brain barrier and to be selectively active on specific brain structures directly involved in asthenia.
Sulbutiamine may reduce fatigue, memory difficulties, intellectual tiredness and may speed convalescence. Because of its fatigue fighting capabilities Sulbutiamine is often used by those who are involved in physically demanding situations. Perhaps more in keeping with other nootropics, Sulbutiamine could promote alertness, strengthens long-term memory, improves reaction time, lowers anxiety, and improves resistance to stress.
What is the function of vitamin B1?
1. Energy Production
Nearly all cells in the body depend on sugar as an energy source. Aerobic energy production is when oxygen converts sugar into a usable energy. This process cannot take place without adequate supplies of vitamin B1.
When vitamin B1 functions in this energy-production capacity, it is usually present in the form of TDP, or thiamin diphosphate. Sulbutiamine is a precursor to thiamine.
Vitamin B1 is vitally important to energy production. As food energy is measured in calories, it is recommended that for every 1000 calories consumed, a 0.5mg of B1 intake is needed.
2. Nervous System Support
Vitamin B1 plays a key role in supporting of the nervous system. It encourages a healthy development of myelin sheaths which are coverings that surround most nerves. A lack of B1 can cause these coverings to become damaged thus creating nerve deadening or pain or prickly sensations.
Vitamin B1 is also involved in the production of the neurotransmitter acetylcholine, a key nervous system molecule which relays messages to nerves and muscles including the heart. Deficiency of B1 can result in compromised heart function.
Vitamin B1 is also known as Thiamin(e). Sulbutiamine is a molecule that crosses the blood-brain barrier more easily than thiamin. Its metabolism in the brain leads to an increase in the levels of thiamine and thiamine phosphate esters.
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- Chronic treatment with sulbutiamine improves memory. – Read Full Article
- Injection of sulbutiamine induces an increase in thiamine triphosphate in rat tissues. – Read Full Article
- Chronic administration of sulbutiamine improves long term memory formation in mice. – Read Full Article
- Facilitation of a state of wakefulness by semi-chronic treatment with sulbutiamin (Arcalion) in Macaca mulatta. – Read Full Article
- Pharmacologic and therapeutic features of sulbutiamine. Drugs Today (Barc). 1999 – Read Full Article
- Potentiometric sensors for the selective determination of sulbutiamine. J Pharm Biomed Anal. 1999 – Read Full Article
- Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease – Read Full Article
- Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuropsychopharmacol Biol Psychiatry. 2005 – Read Full Article
- Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochem Res. 2010 – Read Full Article
- Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo – Read Full Article
- Effects of sulbutiamine (Arcalion 200) on psycho-behavioral inhibition in major depressive episodes – Read Full Article